There is a known issue with the usb module for node.js.
Binding issue on Linux · Issue #37 · nonolith/node-usb · GitHub
I'm running into this problem on the Edison Yocto build: edison-rel1-maint-weekly_build_16_2014-10-14_14-56-19
Any help would be appreciated. If I can't get this working I maybe stuck with some horrible mess like using pyusb in a python script with some linkage between node.js and python. I'd much prefer to resolve this and have a clean server running in node.js. However, resolving binding issues are beyond my skill set.